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Issue 24, 2015
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Nanoparticle-assisted laser desorption/ionization using sinapic acid-modified iron oxide nanoparticles for mass spectrometry analysis

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Abstract

Iron oxide-based nanoparticles (NP) were covalently modified with sinapic acid (SA) through a condensation reaction to assist the ionization of both large and small molecules. The morphology of SA-modified NPs (SA-NP) was characterized by transmission electron microscopy (TEM), and the modification of the NP surface with SA was confirmed using ultraviolet (UV) and infrared (IR) spectroscopy. The number of SA molecules was estimated to be 6 per NP. SA-NP-assisted laser desorption/ionization was carried out on small molecules, such as pesticides and plant hormones, and large molecules, such as peptides and proteins. A peptide fragment from degraded proteins was detected more efficiently compared with conventional methods.

Graphical abstract: Nanoparticle-assisted laser desorption/ionization using sinapic acid-modified iron oxide nanoparticles for mass spectrometry analysis

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Supplementary files

Article information


Submitted
08 Oct 2015
Accepted
19 Oct 2015
First published
20 Oct 2015

Analyst, 2015,140, 8134-8137
Article type
Paper
Author version available

Nanoparticle-assisted laser desorption/ionization using sinapic acid-modified iron oxide nanoparticles for mass spectrometry analysis

H. Komori, R. Hashizaki, I. Osaka, T. Hibi, H. Katano and S. Taira, Analyst, 2015, 140, 8134
DOI: 10.1039/C5AN02081F

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