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Issue 24, 2015
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Using the inherent chemistry of the endothelin-1 peptide to develop a rapid assay for pre-transplant donor lung assessment

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Abstract

Endothelin-1 is a potent vasoconstrictive peptide that plays an important role in ex vivo lung perfusion. ET-1 expression levels are predictive of lung transplant outcomes and represent a valuable monitoring tool for surgeons; however, traditional techniques that measure [ET-1] are not suitable for the transplant setting. Herein, we demonstrate a new assay that rapidly measures ET-1 peptide levels in lung perfusate.

Graphical abstract: Using the inherent chemistry of the endothelin-1 peptide to develop a rapid assay for pre-transplant donor lung assessment

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Publication details

The article was received on 28 Jul 2015, accepted on 30 Oct 2015 and first published on 30 Oct 2015


Article type: Communication
DOI: 10.1039/C5AN01536G
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Citation: Analyst, 2015,140, 8092-8096
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    Using the inherent chemistry of the endothelin-1 peptide to develop a rapid assay for pre-transplant donor lung assessment

    A. T. Sage, X. Bai, M. Cypel, M. Liu, S. Keshavjee and S. O. Kelley, Analyst, 2015, 140, 8092
    DOI: 10.1039/C5AN01536G

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