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Issue 20, 2015
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The application of FAIMS gas analysis in medical diagnostics

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Abstract

There is an ever increasing need to develop new tools to aid in the diagnosis and monitoring of human diseases. Such tools will ultimately reduce the cost of healthcare by identifying disease states more quickly and cheaply than current practices. One method showing promise is the analysis of gas-phase biomarkers from human breath, urine, sweat and stool that reflect bodily metabolism. Analysis of these volatiles by GC MS requires specialised infra-structure and staff, making it unsuitable for a clinical setting. Point of care sensor based technologies such as eNoses often suffer from stability and sensitivity issues. Field-Asymmetric Ion Mobility Spectrometry (FAIMS) has potential to fulfil this clinical need. In this paper we review the medical need, the technology, sampling methods and medical evidence thus far. We conclude with reflecting on future developmental steps necessary to bring the device into medical practice.

Graphical abstract: The application of FAIMS gas analysis in medical diagnostics

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Publication details

The article was received on 01 May 2015, accepted on 16 Jul 2015 and first published on 17 Jul 2015


Article type: Minireview
DOI: 10.1039/C5AN00868A
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Citation: Analyst, 2015,140, 6775-6781

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    The application of FAIMS gas analysis in medical diagnostics

    J. A. Covington, M. P. van. der Schee, A. S. L. Edge, B. Boyle, R. S. Savage and R. P. Arasaradnam, Analyst, 2015, 140, 6775
    DOI: 10.1039/C5AN00868A

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