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Issue 15, 2015
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Plasmonic sensors for the competitive detection of testosterone

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The ability to detect small molecules in a rapid and sensitive manner is of great importance in the field of clinical chemistry, and the advancement of novel biosensors is key to realising point-of-care analysis for essential targets. Testosterone is an example of such a small molecule, the detection of which is important in both clinical analysis, and in the sporting industry to prevent doping. As such, a portable, rapid and sensitive test for testosterone would be of great use across a variety of analytical fields. Here we report on a novel method of testosterone analysis, based on a competitive inhibition assay utilising functionalized gold nanoparticles. Two sensing platforms are directly compared for the detection of testosterone based on both classical SPR and LSPR. We provide an in-depth discussion on the optimum surface chemistries needed to create a stable detection conjugate before successfully detecting testosterone using our newly developed portable 4-channel SPR instrument. We provide the first detailed study into the comparison of SPR and LSPR for the analysis of a small molecule, and provide a simple and effective method of testosterone detection that could potentially be extended to a variety of different analytes.

Graphical abstract: Plasmonic sensors for the competitive detection of testosterone

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The article was received on 10 Apr 2015, accepted on 27 May 2015 and first published on 27 May 2015

Article type: Paper
DOI: 10.1039/C5AN00694E
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Analyst, 2015,140, 5105-5111

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    Plasmonic sensors for the competitive detection of testosterone

    H. Yockell-Lelièvre, N. Bukar, K. S. McKeating, M. Arnaud, P. Cosin, Y. Guo, J. Dupret-Carruel, B. Mougin and J.-F. Masson, Analyst, 2015, 140, 5105
    DOI: 10.1039/C5AN00694E

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