Gold nanoparticle/polymer nanocomposite for highly sensitive drug–DNA interaction

Abstract

The interaction of the anticancer drug mitomycin C (MC) and DNA immobilized on gold a nanoparticle/polyvinylferrocenium (AuNP/PVF⁺) coated electrode is presented. This is the first attempt to prepare a biocompatible nanoparticle/redox polymer composite in a one-step and easy electropolymerization procedure and then use the coated electrode for MC–DNA interaction. The prepared electrode exhibits high sensitivity for the investigation of drug–DNA interaction.