Issue 8, 2015
From the journal:

Analyst

Coupling a solid phase microextraction (SPME) probe with ambient MS for rapid enrichment and detection of phosphopeptides in biological samples†

Yaoyao Zhao,a   Xiaoyun Gong,a   Xingyu Si,a   Zhenwei Wei,a   Chengdui Yang,a   Sichun Zhanga  and  Xinrong Zhang*a  

* Corresponding authors

a Beijing Key Laboratory for Microanalytical Methods and Instrumentation, Department of Chemistry, Tsinghua University, Beijing 10084, China
E-mail: xrzhang@mail.tsinghua.edu.cn
Tel: +86-10-62782485

Abstract

In this study, we developed a probe-electrospray ionization method by coupling a SPME probe modified with nanosized TiO2 directly to nanoESI-MS for the phosphoproteome analysis, which demonstrated excellent selectivity and sensitivity for enrichment of phosphopeptides in complex biological samples.

Graphical abstract: Coupling a solid phase microextraction (SPME) probe with ambient MS for rapid enrichment and detection of phosphopeptides in biological samples

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C4AN02156H
Article type
Communication
Submitted
22 Nov 2014
Accepted
09 Feb 2015
First published
09 Feb 2015

Analyst, 2015,140, 2599-2602

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Coupling a solid phase microextraction (SPME) probe with ambient MS for rapid enrichment and detection of phosphopeptides in biological samples

Y. Zhao, X. Gong, X. Si, Z. Wei, C. Yang, S. Zhang and X. Zhang, Analyst, 2015, 140, 2599 DOI: 10.1039/C4AN02156H

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