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Issue 4, 2015
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Molecular modeling and spectroscopic study of quinone–protein adducts: insight into toxicity, selectivity, and reversibility

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Abstract

The important biological and toxicological roles of quinones could be attributed to their versatile electrophilic and oxidative properties. Quinones are able to undergo Michael addition with cellular thiols such as glutathione and proteins, and promote electron transfer in living systems via redox-cycling. Although the protein adduction of quinones is assumed to be a part of their metabolic fate, the adducts retain the redox-cycling capability of the parent quinones, and thus we can consider the adducts as a type of active metabolite. Herein, the toxicity, reversibility, and selectivity of protein adducts were studied using molecular spectroscopy and molecular modeling.

Graphical abstract: Molecular modeling and spectroscopic study of quinone–protein adducts: insight into toxicity, selectivity, and reversibility

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Publication details

The article was received on 02 Apr 2015, accepted on 06 May 2015 and first published on 07 May 2015


Article type: Communication
DOI: 10.1039/C5TX00098J
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Toxicol. Res., 2015,4, 843-847

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    Molecular modeling and spectroscopic study of quinone–protein adducts: insight into toxicity, selectivity, and reversibility

    M. S. Elgawish, N. Kishikawa, M. A. Helal, K. Ohyama and N. Kuroda, Toxicol. Res., 2015, 4, 843
    DOI: 10.1039/C5TX00098J

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