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Issue 2, 2015
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Manganese-induced neurotoxicity: from C. elegans to humans

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Abstract

Manganese (Mn) is one of the most abundant metals on the earth. It is required for normal cellular activities, but overexposure leads to toxicity. Neurons are more susceptible to Mn-induced toxicity than other cells, and accumulation of Mn in the brain results in Manganism that presents with Parkinson's disease (PD)-like symptoms. In the last decade, a number of Mn transporters have been identified, which improves our understanding of Mn transport in and out of cells. However, the mechanism of Mn-induced neurotoxicity is only partially uncovered, with further research needed to explore the whole picture of Mn-induced toxicity. In this review, we will address recent progress in Mn-induced neurotoxicity from C. elegans to humans, and explore future directions that will help understand the mechanisms of its neurotoxicity.

Graphical abstract: Manganese-induced neurotoxicity: from C. elegans to humans

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Publication details

The article was received on 12 Sep 2014, accepted on 04 Nov 2014 and first published on 06 Nov 2014


Article type: Review Article
DOI: 10.1039/C4TX00127C
Toxicol. Res., 2015,4, 191-202

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    Manganese-induced neurotoxicity: from C. elegans to humans

    P. Chen, S. Chakraborty, T. V. Peres, A. B. Bowman and M. Aschner, Toxicol. Res., 2015, 4, 191
    DOI: 10.1039/C4TX00127C

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