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Issue 2, 2015
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Manganese-induced neurotoxicity: from C. elegans to humans

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Manganese (Mn) is one of the most abundant metals on the earth. It is required for normal cellular activities, but overexposure leads to toxicity. Neurons are more susceptible to Mn-induced toxicity than other cells, and accumulation of Mn in the brain results in Manganism that presents with Parkinson's disease (PD)-like symptoms. In the last decade, a number of Mn transporters have been identified, which improves our understanding of Mn transport in and out of cells. However, the mechanism of Mn-induced neurotoxicity is only partially uncovered, with further research needed to explore the whole picture of Mn-induced toxicity. In this review, we will address recent progress in Mn-induced neurotoxicity from C. elegans to humans, and explore future directions that will help understand the mechanisms of its neurotoxicity.

Graphical abstract: Manganese-induced neurotoxicity: from C. elegans to humans

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Publication details

The article was received on 12 Sep 2014, accepted on 04 Nov 2014 and first published on 06 Nov 2014

Article type: Review Article
DOI: 10.1039/C4TX00127C
Toxicol. Res., 2015,4, 191-202

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    Manganese-induced neurotoxicity: from C. elegans to humans

    P. Chen, S. Chakraborty, T. V. Peres, A. B. Bowman and M. Aschner, Toxicol. Res., 2015, 4, 191
    DOI: 10.1039/C4TX00127C

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