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Issue 15, 2015
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One-pot solvothermal synthesis of biocompatible magnetic nanoparticles mediated by cucurbit[n]urils

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Abstract

We present a facile one-step procedure for the solvothermal synthesis of highly water-dispersible magnetic Fe3O4 nanoparticles mediated by cucurbit[n]urils (CB[n]s). A layer of CB[n]s was coated on the MNP surface via the portal carbonyl groups to avoid MNP agglomeration, and served as a stabilizer to impart the nanoparticles with exceptional dispersibility and stability. Significantly, the nanoparticle sizes can be controlled and fine-tuned by varying the molar ratios of CB[n]s and FeCl3 in solution. The biocompatibility of the materials was investigated by MTT assay using normal human embryonic kidney 293T cells. The synergetic effects of combining supramolecular chemistry with magnetic nanoparticles are promising for clinical diagnosis and transportation of drugs, proteins, viruses, bacteria, etc., which offer important advantageous features for their real applications.

Graphical abstract: One-pot solvothermal synthesis of biocompatible magnetic nanoparticles mediated by cucurbit[n]urils

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Supplementary files

Article information


Submitted
07 Feb 2015
Accepted
11 Mar 2015
First published
12 Mar 2015

J. Mater. Chem. C, 2015,3, 3517-3521
Article type
Communication

One-pot solvothermal synthesis of biocompatible magnetic nanoparticles mediated by cucurbit[n]urils

X. Qiu, Y. Zhou, X. Jin, A. Qi and Y. Yang, J. Mater. Chem. C, 2015, 3, 3517 DOI: 10.1039/C5TC00369E

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