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Issue 47, 2015
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Single step synthesis of carbon dot embedded chitosan nanoparticles for cell imaging and hydrophobic drug delivery

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Abstract

The florescent carbon dot conjugated chitosan nanoparticles are developed for the cellular imaging and delivery of poorly water soluble drug telmisartan (TEL). In this work, the florescent chitosan nanoparticles are synthesized in a single step. The presence of surface functional groups and conjugation of the nanoparticles are investigated by FTIR spectroscopy. Dynamic light scattering and TEM analysis are performed to determine the size of the nanoparticles. To investigate the surface morphology FESEM analysis is also performed. The cytotoxicity of the nanoparticles is examined by MTT assay using normal lymphocytes and KG1A cancer cell lines. The intracellular cellular uptake is studied by fluorescence microscopy and flow cytometry analysis. The interactions between the nanoparticles and the drug are investigated by Gaussian 09 and visualized by GaussView 5 program package.

Graphical abstract: Single step synthesis of carbon dot embedded chitosan nanoparticles for cell imaging and hydrophobic drug delivery

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Publication details

The article was received on 04 Sep 2015, accepted on 22 Oct 2015 and first published on 22 Oct 2015


Article type: Paper
DOI: 10.1039/C5TB01831E
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J. Mater. Chem. B, 2015,3, 9122-9131

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    Single step synthesis of carbon dot embedded chitosan nanoparticles for cell imaging and hydrophobic drug delivery

    A. Ray Chowdhuri, S. Tripathy, C. Haldar, S. Roy and S. K. Sahu, J. Mater. Chem. B, 2015, 3, 9122
    DOI: 10.1039/C5TB01831E

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