Jump to main content
Jump to site search
SCHEDULED MAINTENANCE Close the message box

Maintenance work is planned for Monday 16 August 2021 from 07:00 to 23:59 (BST).

Website performance may be temporarily affected and you may not be able to access some PDFs or images. If this does happen, refreshing your web browser should resolve the issue. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 46, 2015

Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells

Author affiliations

Abstract

Herein, we report the synthesis and characterization of nanospheres of a biodegradable zinc-imidazolate polymers (ZIPs) as a proof-of-concept delivery vehicle into human brain endothelial cells, the main component of the blood-brain barrier (BBB). The ZIP particles can readily encapsulate functional molecules such as fluorophores and inorganic nanoparticles at the point of synthesis producing stable colloidal dispersions. Our results show that these biodegradable particles are not cytotoxic, and are able to penetrate and release cargo species to human brain capillary endothelial cells in vitro thus exhibiting significant potential as a novel platform for brain targeting treatments.

Graphical abstract: Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells

Supplementary files

Article information


Submitted
02 Sep 2015
Accepted
23 Oct 2015
First published
26 Oct 2015

This article is Open Access

J. Mater. Chem. B, 2015,3, 9053-9059
Article type
Paper
Author version available

Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells

M. Chiacchia, C. Cerutti, R. Gromnicova, K. Rietdorf, I. A. Romero and D. Bradshaw, J. Mater. Chem. B, 2015, 3, 9053 DOI: 10.1039/C5TB01814E

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements