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Issue 11, 2015
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Biocompatible small peptide super-hydrogelators bearing carbazole functionalities

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Abstract

For the first time we have introduced carbazole capping groups onto two short peptide sequences, namely a diphenylalanine dipeptide and a glycine–diphenylalanine tripeptide, giving compounds 1 and 2, respectively. Both molecules form hydrogels at low concentrations, as low as 0.03% (w/v) for 1 – well within the range of supergelators. Both gelators are composed of small ca. 2 nm thick molecular fibres, as elucidated by AFM and are non-cytotoxic towards HeLa cells at concentrations which are at or above their minimum gelation concentration.

Graphical abstract: Biocompatible small peptide super-hydrogelators bearing carbazole functionalities

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Supplementary files

Article information


Submitted
12 Jan 2015
Accepted
15 Feb 2015
First published
17 Feb 2015

J. Mater. Chem. B, 2015,3, 2277-2280
Article type
Communication
Author version available

Biocompatible small peptide super-hydrogelators bearing carbazole functionalities

A. D. Martin, A. B. Robinson and P. Thordarson, J. Mater. Chem. B, 2015, 3, 2277
DOI: 10.1039/C5TB00067J

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