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Issue 11, 2015
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Amine functionalized ZrO2 nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging

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Abstract

Surface functionalized ZrO2 nanoparticles show strong photoluminescence and are a versatile tool for cellular targeting due to their chemical functionality. They are highly photostable, biocompatible and amenable to coupling with bioligands (e.g. secondary goat anti-rabbit antibody (GAR) and tri-phenyl phosphine (TPP)) via carbodiimide chemistry. Antibody (GAR) functionalized ZrO2 nanoparticles were used to image the nuclear protein Sirt6, whereas triphenyl phosphonium ion (TPP) functionalized ZrO2 nanoparticles specifically targeted the mitochondria. The versatility and easiness of the ZrO2 surface modification opens up new possibilities for designing non-toxic water dispersible and photostable photoluminescent NPs.

Graphical abstract: Amine functionalized ZrO2 nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging

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Publication details

The article was received on 26 Nov 2014, accepted on 03 Feb 2015 and first published on 09 Feb 2015


Article type: Paper
DOI: 10.1039/C4TB01959H
J. Mater. Chem. B, 2015,3, 2371-2377

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    Amine functionalized ZrO2 nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging

    M. N. Tahir, R. Ragg, F. Natalio, J. K. Sahoo, P. Daniel, K. Koynov, D. Strand, S. Strand and W. Tremel, J. Mater. Chem. B, 2015, 3, 2371
    DOI: 10.1039/C4TB01959H

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