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Issue 12, 2015
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Periodically tailored titania nanotubes for enhanced drug loading and releasing performances

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Abstract

The structural engineering of titania nanotubes (TNTs) using electrochemical anodization was performed to generate periodically modulated (p-TNTs) internal structures by applying an oscillatory voltage during the anodization process to demonstrate their improved drug-loading and drug-releasing properties. Drug loading and in vitro drug release studies compared with conventional TNTs with flat structures suggested considerable improvement with increased drug loading, reduced burst release and extended drug release for over 2 weeks. Furthermore, p-TNTs arrays were fractured by ultrasonication into liberated TNTs capsules and their potential applications as drug micro/nano-carriers for targeted and localized drug delivery is proposed. The presented electrochemical approach for structural engineering of TNTs provides new prospects in designing TNTs drug releasing implants with advanced drug-loading/release characteristics for localized drug delivery. Such implant modifications can further be tailored to cater for various implant challenges and bone therapies like: inflammation, infection and poor implant integration.

Graphical abstract: Periodically tailored titania nanotubes for enhanced drug loading and releasing performances

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Article information


Submitted
14 Nov 2014
Accepted
16 Feb 2015
First published
18 Feb 2015

J. Mater. Chem. B, 2015,3, 2553-2559
Article type
Paper
Author version available

Periodically tailored titania nanotubes for enhanced drug loading and releasing performances

K. Gulati, K. Kant, D. Findlay and D. Losic, J. Mater. Chem. B, 2015, 3, 2553
DOI: 10.1039/C4TB01882F

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