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Issue 5, 2015
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Rational design of a hexapeptide hydrogelator for controlled-release drug delivery

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Abstract

The amphiphilic peptide sequence H-Phe-Glu-Phe-Gln-Phe-Lys-OH (MBG-1) is developed as a novel hydrogelator for use in controlled-drug release administration, which is the smallest tunable ionic self-complementary hydrogelating peptide reported to date making it attractive for larger scale preparation. Hydrogelation is demonstrated to result from self-assembly of the peptide into beta-sheet nanofibers that are physically cross-linked by intertwining as well as larger bundle formation. Finally, the release of two small molecule cargos, fluorescein sodium and ciprofloxacin hydrochloride, is demonstrated revealing a two-stage zero-order sustained release profile up to 80% cumulative release over eight days.

Graphical abstract: Rational design of a hexapeptide hydrogelator for controlled-release drug delivery

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Supplementary files

Article information


Submitted
04 Aug 2014
Accepted
11 Nov 2014
First published
18 Nov 2014

J. Mater. Chem. B, 2015,3, 759-765
Article type
Paper
Author version available

Rational design of a hexapeptide hydrogelator for controlled-release drug delivery

M. Bibian, J. Mangelschots, J. Gardiner, L. Waddington, M. M. Diaz Acevedo, B. G. De Geest, B. Van Mele, A. Madder, R. Hoogenboom and S. Ballet, J. Mater. Chem. B, 2015, 3, 759
DOI: 10.1039/C4TB01294A

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