Jump to main content
Jump to site search

Issue 42, 2015
Previous Article Next Article

Anomalous and anisotropic nanoscale diffusion of hydration water molecules in fluid lipid membranes

Author affiliations

Abstract

We have studied nanoscale diffusion of membrane hydration water in fluid-phase lipid bilayers made of 1,2-dimyristoyl-3-phosphocholine (DMPC) using incoherent quasi-elastic neutron scattering. Dynamics were fit directly in the energy domain using the Fourier transform of a stretched exponential. By using large, 2-dimensional detectors, lateral motions of water molecules and motions perpendicular to the membranes could be studied simultaneously, resulting in 2-dimensional maps of relaxation time, τ, and stretching exponent, β. We present experimental evidence for anomalous (sub-diffusive) and anisotropic diffusion of membrane hydration water molecules over nanometer distances. By combining molecular dynamics and Brownian dynamics simulations, the potential microscopic origins for the anomaly and anisotropy of hydration water were investigated. Bulk water was found to show intrinsic sub-diffusive motion at time scales of several picoseconds, likely related to caging effects. In membrane hydration water, however, the anisotropy of confinement and local dynamical environments leads to an anisotropy of relaxation times and stretched exponents, indicative of anomalous dynamics.

Graphical abstract: Anomalous and anisotropic nanoscale diffusion of hydration water molecules in fluid lipid membranes

Back to tab navigation

Article information


Submitted
11 Jul 2015
Accepted
18 Aug 2015
First published
19 Aug 2015

This article is Open Access

Soft Matter, 2015,11, 8354-8371
Article type
Paper

Anomalous and anisotropic nanoscale diffusion of hydration water molecules in fluid lipid membranes

L. Toppozini, F. Roosen-Runge, R. I. Bewley, R. M. Dalgliesh, T. Perring, T. Seydel, H. R. Glyde, V. García Sakai and M. C. Rheinstädter, Soft Matter, 2015, 11, 8354
DOI: 10.1039/C5SM01713K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements