Jump to main content
Jump to site search

Issue 45, 2015
Previous Article Next Article

Hydrophobic nanoparticles promote lamellar to inverted hexagonal transition in phospholipid mesophases

Author affiliations

Abstract

This study focuses on how the mesophase transition behaviour of the phospholipid dioleoyl phosphatidylethanolamine (DOPE) is altered by the presence of 10 nm hydrophobic and 14 nm hydrophilic silica nanoparticles (NPs) at different concentrations. The lamellar to inverted hexagonal phase transition (Lα–HII) of phospholipids is energetically analogous to the membrane fusion process, therefore understanding the Lα–HII transition with nanoparticulate additives is relevant to how membrane fusion may be affected by these additives, in this case the silica NPs. The overriding observation is that the HII/Lα boundaries in the DOPE p–T phase diagram were shifted by the presence of NPs: the hydrophobic NPs enlarged the HII phase region and thus encouraged the inverted hexagonal (HII) phase to occur at lower temperatures, whilst hydrophilic NPs appeared to stabilise the Lα phase region. This effect was also NP-concentration dependent, with a more pronounced effect for higher concentration of the hydrophobic NPs, but the trend was less clear cut for the hydrophilic NPs. There was no evidence that the NPs were intercalated into the mesophases, and as such it was likely that they might have undergone microphase separation and resided at the mesophase domain boundaries. Whilst the loci and exact roles of the NPs invite further investigation, we tentatively discuss these results in terms of both the surface chemistry of the NPs and the effect of their curvature on the elastic bending energy considerations during the mesophase transition.

Graphical abstract: Hydrophobic nanoparticles promote lamellar to inverted hexagonal transition in phospholipid mesophases

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Jul 2015, accepted on 14 Sep 2015 and first published on 15 Sep 2015


Article type: Paper
DOI: 10.1039/C5SM01705J
Soft Matter, 2015,11, 8789-8800
  • Open access: Creative Commons BY license
  •   Request permissions

    Hydrophobic nanoparticles promote lamellar to inverted hexagonal transition in phospholipid mesophases

    J. M. Bulpett, T. Snow, B. Quignon, C. M. Beddoes, T-Y. D. Tang, S. Mann, O. Shebanova, C. L. Pizzey, N. J. Terrill, S. A. Davis and W. H. Briscoe, Soft Matter, 2015, 11, 8789
    DOI: 10.1039/C5SM01705J

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements