Issue 25, 2015

Protein dynamics: from rattling in a cage to structural relaxation

Abstract

We present an overview of protein dynamics based mostly on results of neutron scattering, dielectric relaxation spectroscopy and molecular dynamics simulations. We identify several major classes of protein motions on the time scale from faster than picoseconds to several microseconds, and discuss the coupling of these processes to solvent dynamics. Our analysis suggests that the microsecond backbone relaxation process might be the main structural relaxation of the protein that defines its glass transition temperature, while faster processes present some localized secondary relaxations. Based on the overview, we formulate a general picture of protein dynamics and discuss the challenges in this field.

Graphical abstract: Protein dynamics: from rattling in a cage to structural relaxation

Article information

Article type
Review Article
Submitted
17 Mar 2015
Accepted
22 May 2015
First published
01 Jun 2015
This article is Open Access
Creative Commons BY license

Soft Matter, 2015,11, 4984-4998

Author version available

Protein dynamics: from rattling in a cage to structural relaxation

S. Khodadadi and A. P. Sokolov, Soft Matter, 2015, 11, 4984 DOI: 10.1039/C5SM00636H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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