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Issue 22, 2015
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Nonthermal fluctuations of the mitotic spindle

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We present direct measurements of fluctuations in the nucleus of yeast cells. While prior work has shown these fluctuations to be active and non-thermal in character, their origin and time dependence are not understood. We show that the nuclear fluctuations we observe are quantitatively consistent with uncorrelated, active force fluctuations driving a nuclear medium that is dominated by an uncondensed DNA solution, for which we perform rheological measurements on an in vitro model system under similar conditions to what is expected in the nucleus.

Graphical abstract: Nonthermal fluctuations of the mitotic spindle

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The article was received on 19 Jan 2015, accepted on 15 Apr 2015 and first published on 15 Apr 2015

Article type: Paper
DOI: 10.1039/C5SM00149H
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Soft Matter, 2015,11, 4396-4401

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    Nonthermal fluctuations of the mitotic spindle

    K. Smith, B. Griffin, H. Byrd, F. C. MacKintosh and M. L. Kilfoil, Soft Matter, 2015, 11, 4396
    DOI: 10.1039/C5SM00149H

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