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Issue 14, 2015
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A tadpole-shaped gene carrier with distinct phase segregation in a ternary polymeric micelle

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Abstract

A distinct tadpole-shaped nanostructure characterized by a spherical head and an extended shaft was identified in a single plasmid DNA (pDNA)-based polymeric micelle. The tadpole-shaped structure was constructed by adding anionic chondroitin sulfate (CS) to the rod-shaped polyplex micelle containing a single pDNA molecule packaged by the PEG-polycation block copolymer through their electrostatic self-assembly. The complex consequently developed a novel structure composed of segregated domains of the CS-rich inflated head and CS-poor folded DNA tail. Hence, this tadpole structure can be regarded as evidence that distinct phase segregation occurred in a single polymeric micelle containing pDNA.

Graphical abstract: A tadpole-shaped gene carrier with distinct phase segregation in a ternary polymeric micelle

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Publication details

The article was received on 22 Dec 2014, accepted on 19 Feb 2015 and first published on 25 Feb 2015


Article type: Communication
DOI: 10.1039/C4SM02850C
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Soft Matter, 2015,11, 2718-2722

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    A tadpole-shaped gene carrier with distinct phase segregation in a ternary polymeric micelle

    Q. Chen, K. Osada, M. Pennisi, S. Uchida, T. A. Tockary, A. Dirisala, Y. Li, K. M. Takeda, S. Oniyanagi, K. Itaka and K. Kataoka, Soft Matter, 2015, 11, 2718
    DOI: 10.1039/C4SM02850C

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