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Issue 10, 2015
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Pd(ii)-catalyzed remote regiodivergent ortho- and meta-C–H functionalizations of phenylethylamines

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Abstract

Site selectivity control is of vital importance in the direct functionalization of inert C–H bonds. Reported here is a novel example of remote regiodivergent ortho- and meta-C–H bond functionalizations of phenylethylamine derivatives by using a novel 2-cyanobenzoyl group as the original directing functionality, where the regioselectivity was adjusted by a methylation. The potential of the method was exemplified by sequential functionalizations of both ortho- and meta-C–H bonds of a phenylethylamine derivative in a streamlined manner.

Graphical abstract: Pd(ii)-catalyzed remote regiodivergent ortho- and meta-C–H functionalizations of phenylethylamines

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Article information


Submitted
12 May 2015
Accepted
24 Jun 2015
First published
25 Jun 2015

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2015,6, 5595-5600
Article type
Edge Article

Pd(II)-catalyzed remote regiodivergent ortho- and meta-C–H functionalizations of phenylethylamines

S. Li, H. Ji, L. Cai and G. Li, Chem. Sci., 2015, 6, 5595 DOI: 10.1039/C5SC01737H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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