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Issue 3, 2015
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Stimuli-responsive metal–organic frameworks gated by pillar[5]arene supramolecular switches

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Abstract

Spurred on by recent advances in materials chemistry and drug delivery, a new stimuli-responsive theranostic hybrid platform, based on mechanized monodisperse nano metal–organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered cargo release capabilities, has been constructed for the first time. This nanoscale smart cargo delivery system showed pH- and/or competitive binding agent-triggered controlled cargo release with negligible premature release, large pore sizes for drug encapsulation, low cytotoxicity, good biodegradability and biocompatibility, and potential application in cell imaging, which offers a new tool in targeted drug delivery and the controlled release of therapeutic agents.

Graphical abstract: Stimuli-responsive metal–organic frameworks gated by pillar[5]arene supramolecular switches

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Supplementary files

Article information


Submitted
04 Dec 2014
Accepted
24 Dec 2014
First published
24 Dec 2014

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2015,6, 1640-1644
Article type
Edge Article

Stimuli-responsive metal–organic frameworks gated by pillar[5]arene supramolecular switches

L. Tan, H. Li, Y. Qiu, D. Chen, X. Wang, R. Pan, Y. Wang, S. X. Zhang, B. Wang and Y. Yang, Chem. Sci., 2015, 6, 1640
DOI: 10.1039/C4SC03749A

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