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Issue 115, 2015
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Nanospheres from the self-assembly of an elastin-inspired triblock peptide

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Abstract

Peptide-based biomaterials are gaining increasing interest as biomaterials for tissue engineering as well as drug delivery systems. Many studies were conducted on amphiphilic or surfactant peptides, showing the great plethora of nanostructures that they can form, according to sequence and experimental conditions. In our work we were interested in the effect of secondary structure propensity of the peptide on the self-assembling properties. A designed peptide, having a conformation-based three-block structure, was able to form nanospheres of 100–400 nm diameter. The molecular and supramolecular structure was investigated by several biophysical techniques and highlights the important role of conformational flexibility and π–π stacking in the self-assembly of the peptide.

Graphical abstract: Nanospheres from the self-assembly of an elastin-inspired triblock peptide

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Supplementary files

Article information


Submitted
12 Oct 2015
Accepted
29 Oct 2015
First published
29 Oct 2015

RSC Adv., 2015,5, 95007-95013
Article type
Paper
Author version available

Nanospheres from the self-assembly of an elastin-inspired triblock peptide

A. Scelsi, B. Bochicchio, A. Smith, A. Saiani and A. Pepe, RSC Adv., 2015, 5, 95007
DOI: 10.1039/C5RA21182D

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