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Issue 95, 2015
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Chemoselective calcium-catalysed direct amidation of carboxylic esters

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Abstract

Unactivated carboxylic esters and primary amines undergo calcium-catalysed direct amide bond formation in excellent yields under homogeneous conditions in toluene. This green and mild reaction proceeds chemoselectively with esters, whereas related carboxylic acids and amides remain unreactive.

Graphical abstract: Chemoselective calcium-catalysed direct amidation of carboxylic esters

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Supplementary files

Article information


Submitted
16 Jul 2015
Accepted
09 Sep 2015
First published
09 Sep 2015

RSC Adv., 2015,5, 77658-77661
Article type
Communication

Chemoselective calcium-catalysed direct amidation of carboxylic esters

D. T. Nguyen, D. C. Lenstra and J. Mecinović, RSC Adv., 2015, 5, 77658
DOI: 10.1039/C5RA18288C

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