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Issue 95, 2015
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Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein

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Abstract

The photochemical properties of phenyl azide have been exploited to modulate the function of a red autofluorescent protein, mCherry. Using genetic code reprogramming, phenyl azide chemistry has been introduced at functionally strategic positions in mCherry leading to deactivation, activation or enhancement upon UV irradiation.

Graphical abstract: Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein

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Article information


Submitted
10 Jul 2015
Accepted
07 Sep 2015
First published
08 Sep 2015

This article is Open Access

RSC Adv., 2015,5, 77734-77738
Article type
Communication
Author version available

Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein

S. C. Reddington, S. Driezis, A. M. Hartley, P. D. Watson, P. J. Rizkallah and D. D. Jones, RSC Adv., 2015, 5, 77734
DOI: 10.1039/C5RA13552D

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