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Issue 93, 2015
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Kinetic study of DNA hybridization on DNA-modified gold nanoparticles with engineered nano-interfaces†

Akari Takashimaa  and  Motoi Oishi*a  
Author affiliations

* Corresponding authors

a Division of Materials Science, Faculty of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8573, Japan
E-mail: oishi@ims.tsukuba.ac.jp
Tel: +81-29-853-5935

Abstract

Colorimetric DNA sensing systems using DNA-modified gold nanoparticles (GNPs) rely on DNA hybridization events on the GNP. We report a systematic study of DNA hybridization kinetics on GNPs with different surface modifications using probe DNA and different molecular weight PEGs. The DNA hybridization kinetics are extremely sensitive not only to probe DNA density but also to the molecular weight of PEG.

Graphical abstract: Kinetic study of DNA hybridization on DNA-modified gold nanoparticles with engineered nano-interfaces

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Article information

https://doi.org/10.1039/C5RA13116B
Submitted
06 Jul 2015
Accepted
01 Sep 2015
First published
02 Sep 2015
RSC Adv., 2015,5, 76014-76018
Article type
Communication
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Kinetic study of DNA hybridization on DNA-modified gold nanoparticles with engineered nano-interfaces

A. Takashima and M. Oishi, RSC Adv., 2015, 5, 76014
DOI: 10.1039/C5RA13116B

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