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Issue 47, 2015
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Mn doped ZrO2 as a green, efficient and reusable heterogeneous catalyst for the multicomponent synthesis of pyrano[2,3-d]-pyrimidine derivatives

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Abstract

A simple and an efficient method has been developed for the one-pot multicomponent synthesis of pyrano[2,3-d]-pyrimidine derivatives. This was achieved through the condensation reaction between dimethylbarbituric acid, aromatic aldehyde and malononitrile in the presence of a Mn/ZrO2 heterogeneous catalyst with ethanol/water mixture as solvent for only 1 hour. Further advantages of this synthesis methodology include excellent yields, mild reaction conditions, atom economy, environmentally friendliness, reusable catalyst and no need for chromatographic separations.

Graphical abstract: Mn doped ZrO2 as a green, efficient and reusable heterogeneous catalyst for the multicomponent synthesis of pyrano[2,3-d]-pyrimidine derivatives

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Publication details

The article was received on 09 Apr 2015, accepted on 17 Apr 2015 and first published on 20 Apr 2015


Article type: Communication
DOI: 10.1039/C5RA06373F
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RSC Adv., 2015,5, 37360-37366

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    Mn doped ZrO2 as a green, efficient and reusable heterogeneous catalyst for the multicomponent synthesis of pyrano[2,3-d]-pyrimidine derivatives

    S. N. Maddila, S. Maddila, W. E. van Zyl and S. B. Jonnalagadda, RSC Adv., 2015, 5, 37360
    DOI: 10.1039/C5RA06373F

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