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Issue 52, 2015
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Synthesis of surface nano-molecularly imprinted polymers for sensitive baicalin detection in biological samples

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Abstract

Surface molecularly imprinted polymers (MIP@SBA-15) imprinted on the surface of hybrid nanostructured organic/inorganic materials (SBA-15) were prepared for the selective extraction and detection of baicalin (BA) in biological samples. The surface morphologies and characteristics of the imprinted and non-imprinted polymers were characterized by Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA) and nitrogen adsorption–desorption isotherms. The results indicated that the polymers were successfully grafted onto the surface of SBA-15 and possessed a highly ordered mesoporous structure. In binding tests, MIP@SBA-15 reached saturated adsorption within 80 min and exhibited significant specific recognition toward BA with a large adsorption capacity. In addition, the prepared MIP@SBA-15 was used as a selective sorbent for solid-phase extraction of BA from biological samples. Recoveries of BA from the liver and spleen ranged from 90.6% to 90.9% with RSD <3.7%. All these results reveal that this method is simple, rapid and sensitive for effectively extracting and detecting trace BA in biological samples.

Graphical abstract: Synthesis of surface nano-molecularly imprinted polymers for sensitive baicalin detection in biological samples

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Article information


Submitted
13 Mar 2015
Accepted
20 Apr 2015
First published
22 Apr 2015

RSC Adv., 2015,5, 41377-41384
Article type
Paper

Synthesis of surface nano-molecularly imprinted polymers for sensitive baicalin detection in biological samples

X. Gu, H. He, C. Wang, Y. Gao, H. Zhang, J. Hong, S. Du, L. Chen and C. Yuan, RSC Adv., 2015, 5, 41377
DOI: 10.1039/C5RA04424C

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