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Issue 10, 2015
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Multi-omics based changes in response to cadmium toxicity in Bacillus licheniformis A

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Abstract

Cadmium (Cd), a widespread substance with high toxicity and persistence, is known to cause a broad range of adverse effects in all living organisms. However, many microorganisms have special detoxification mechanisms for Cd. In this study, we investigated the response to Cd in Bacillus licheniformis A at the omics level. Proteomic biomarkers were identified, including peroxiredoxin, nucleoside diphosphate kinase, trigger factor, and elongation factor Tu. These proteins suggested that Cd could induce oxidative stress, disturbance in energy metabolism, and protein synthesis in B. licheniformis A. Furthermore, metabolites (glutamate, glycine, and S-adenosylhomocysteine) involved in the glutathione synthesis pathway were also affected. In addition, some metabolic biomarkers were validated by relating to respective proteins, including 50S ribosomal protein L7/L12, trigger factor, peroxiredoxin and superoxide dismutase in B. licheniformis A. This study provides new insights into the utilization of an omics approach in bacteria to assess the effects of Cd pollution in the environment.

Graphical abstract: Multi-omics based changes in response to cadmium toxicity in Bacillus licheniformis A

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Publication details

The article was received on 26 Nov 2014, accepted on 19 Dec 2014 and first published on 19 Dec 2014


Article type: Paper
DOI: 10.1039/C4RA15280H
RSC Adv., 2015,5, 7330-7339

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    Multi-omics based changes in response to cadmium toxicity in Bacillus licheniformis A

    J. Sun, J. Zhou, Z. Wang, W. He, D. Zhang, Q. Tong and X. Su, RSC Adv., 2015, 5, 7330
    DOI: 10.1039/C4RA15280H

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