Issue 19, 2015
From the journal:

RSC Advances

Regioselective synthesis and theoretical studies of an anti-neoplastic fluoro-substituted dispiro-oxindole†

Adel S. Girgis,ab   Siva S. Panda,a   El-Sayed M. Shalaby,c   Ahmed F. Mabied,c   Peter J. Steel,d   C. Dennis Hall*a  and  Alan R. Katritzky‡ae  

* Corresponding authors

a Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
E-mail: charlesdennishall@gmail.com
Fax: +1-352-392-9199
Tel: +1-352-392-0554

b Pesticide Chemistry Department, National Research Centre, Dokki, Cairo 12622, Egypt

c X-Ray Crystallography Lab., Physics Division, National Research Centre, Dokki, Cairo 12622, Egypt

d Chemistry Department, University of Canterbury, Christchurch, New Zealand

e Department of Chemistry, King Abdulaziz University, Jeddah, Saudi Arabia

Abstract

Single crystal X-ray studies of regioselectively synthesized fluoro-substituted dispiro-oxindole 9 revealed that the structure belongs to the monoclinic space group P21/n with four molecules in the unit cell. The structure was also investigated by AM1, PM3, and DFT studies. Compound 9 exhibits high potency against the HeLa cell line.

Graphical abstract: Regioselective synthesis and theoretical studies of an anti-neoplastic fluoro-substituted dispiro-oxindole

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Article information

DOI
https://doi.org/10.1039/C4RA13433H
Article type
Communication
Submitted
29 Oct 2014
Accepted
13 Jan 2015
First published
13 Jan 2015

RSC Adv., 2015,5, 14780-14787

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Regioselective synthesis and theoretical studies of an anti-neoplastic fluoro-substituted dispiro-oxindole

A. S. Girgis, S. S. Panda, E. M. Shalaby, A. F. Mabied, P. J. Steel, C. D. Hall and A. R. Katritzky, RSC Adv., 2015, 5, 14780 DOI: 10.1039/C4RA13433H

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