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Issue 9, 2015
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Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups

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Abstract

Transition metal-catalyzed direct functionalization of C–H bonds is one of the key emerging strategies that is currently attracting tremendous attention with the aim to provide alternative environmentally friendly and efficient ways for the construction of C–C and C–hetero bonds. In particular, the strategy involving regioselective C–H activation assisted by various functional groups shows high potential, and significant achievements have been made in both the development of novel reactions and the mechanistic study. In this review, we attempt to give an overview of the development of utilizing the functionalities as directing groups. The discussion is directed towards the use of different functional groups as directing groups for the construction of C–C and C–hetero bonds via C–H activation using various transition metal catalysts. The synthetic applications and mechanistic features of these transformations will be discussed, and the review is organized on the basis of the type of directing groups and the type of bond being formed or the catalyst.

Graphical abstract: Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups

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Article information


Submitted
02 Jan 2015
Accepted
02 Jun 2015
First published
03 Jun 2015

Org. Chem. Front., 2015,2, 1107-1295
Article type
Review Article
Author version available

Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups

Z. Chen, B. Wang, J. Zhang, W. Yu, Z. Liu and Y. Zhang, Org. Chem. Front., 2015, 2, 1107
DOI: 10.1039/C5QO00004A

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