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Issue 30, 2015
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Aqueous asymmetric aldol reactions in polymersome membranes

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Abstract

L-Proline catalysts have been immobilised in the hydrophobic domain of a polymersome via a copper(I)-catalysed azide–alkyne cycloaddition (CuAAC) reaction. Utilisation of these nanoreactors in the asymmetric aldol reaction of cyclohexanone with 4-nitrobenzaldehyde afforded the corresponding β-hydroxyketones in quantitative yields and with excellent enantio- and diastereoselectivities. The polymersomes were recycled up to five times without any loss in activity or selectivity.

Graphical abstract: Aqueous asymmetric aldol reactions in polymersome membranes

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Article information


Submitted
08 Jun 2015
Accepted
29 Jun 2015
First published
03 Jul 2015

This article is Open Access

Polym. Chem., 2015,6, 5358-5361
Article type
Communication
Author version available

Aqueous asymmetric aldol reactions in polymersome membranes

M. C. M. van Oers, W. S. Veldmate, J. C. M. van Hest and F. P. J. T. Rutjes, Polym. Chem., 2015, 6, 5358
DOI: 10.1039/C5PY00872G

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