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Issue 23, 2015

Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII

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Abstract

A series of 2/3/4-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)amino]benzenesulfonamides, obtained from substituted isatins and 2-, 3- or 4-aminobenzenesulfonamide, showed low nanomolar inhibitory activity against the tumor associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII – recently validated antitumor drug targets, being much less effective as inhibitors of the off-target cytosolic isoforms CA I and II.

Graphical abstract: Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII

Article information


Submitted
07 Apr 2015
Accepted
27 Apr 2015
First published
27 Apr 2015

This article is Open Access

Org. Biomol. Chem., 2015,13, 6493-6499
Article type
Paper
Author version available

Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII

Ö. Güzel-Akdemir, A. Akdemir, N. Karalı and C. T. Supuran, Org. Biomol. Chem., 2015, 13, 6493 DOI: 10.1039/C5OB00688K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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