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Issue 18, 2015
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Iron- or silver-catalyzed oxidative fluorination of cyclopropanols for the synthesis of β-fluoroketones

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Abstract

The FeIII- or AgI-catalyzed oxidative fluorination of cyclopropanols via radical rearrangement is disclosed. This process features a straightforward and highly effective protocol for the site-specific synthesis of β-fluoroketones and represents an expedient method for the synthesis of γ-, δ- and ε-fluoroketones. Notably, this reaction proceeds at room temperature and tolerates a diverse array of cyclopropanols.

Graphical abstract: Iron- or silver-catalyzed oxidative fluorination of cyclopropanols for the synthesis of β-fluoroketones

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Supplementary files

Article information


Submitted
31 Mar 2015
Accepted
02 Apr 2015
First published
02 Apr 2015

Org. Biomol. Chem., 2015,13, 5105-5109
Article type
Communication
Author version available

Iron- or silver-catalyzed oxidative fluorination of cyclopropanols for the synthesis of β-fluoroketones

S. Ren, C. Feng and T. Loh, Org. Biomol. Chem., 2015, 13, 5105
DOI: 10.1039/C5OB00632E

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