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Issue 19, 2015
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Silver salts and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols with trifluoromethyl ketones

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Abstract

A general and efficient synthesis of trifluoromethyl substituted 5-alkylidene-1,3-dioxolane using a silver salt and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols and trifluoromethyl ketones is described. The procedure produced 5-alkylidene-1,3-dioxolane derivatives with good to excellent yields and can be used with a broad range of substrates.

Graphical abstract: Silver salts and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols with trifluoromethyl ketones

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Publication details

The article was received on 05 Mar 2015, accepted on 02 Apr 2015 and first published on 10 Apr 2015


Article type: Paper
DOI: 10.1039/C5OB00438A
Org. Biomol. Chem., 2015,13, 5399-5406

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    Silver salts and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols with trifluoromethyl ketones

    J. Wang, W. Kong, F. Li, J. Liu, Q. Shen, L. Liu and W. Zhao, Org. Biomol. Chem., 2015, 13, 5399
    DOI: 10.1039/C5OB00438A

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