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Issue 17, 2015
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An efficient approach to 1,2,3-trisubstituted indole via rhodium catalyzed carbene Csp3–H bond insertion

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Abstract

A method for convenient synthesis of N-alkyl-2-aryl-indole-3-carbaldehyde has been described. A variety of highly valuable indolyl aldehydes have been prepared through this method. Electron donating groups on both aromatic rings (anilinyl and benzyl) facilitate the formation of the desired products. A benzylic C–H insertion by rhodium carbene is the key step for this transformation.

Graphical abstract: An efficient approach to 1,2,3-trisubstituted indole via rhodium catalyzed carbene Csp3–H bond insertion

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Article information


Submitted
15 Jan 2015
Accepted
23 Mar 2015
First published
23 Mar 2015

Org. Biomol. Chem., 2015,13, 4851-4854
Article type
Communication
Author version available

An efficient approach to 1,2,3-trisubstituted indole via rhodium catalyzed carbene Csp3–H bond insertion

M. Shen, Y. Pan, Z. Jia, X. Ren, P. Zhang and H. Xu, Org. Biomol. Chem., 2015, 13, 4851 DOI: 10.1039/C5OB00085H

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