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Issue 19, 2015
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Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7

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Abstract

Evasion of apoptosis is one of the six initially proposed hallmarks of cancer, and as such, a method to detect apoptosis in a tumour would be of considerable interest in both clinical trials of new cancer therapeutics, as well as for routine patient management. Activation of caspase-3/7 is a key biomarker of cellular apoptosis. Herein we describe the design, synthesis and initial characterisation of the first pyrimidoindolone compound for detection of caspase-3/7 activation using positron emission tomography.

Graphical abstract: Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7

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Publication details

The article was received on 12 Jan 2015, accepted on 30 Mar 2015 and first published on 02 Apr 2015


Article type: Paper
DOI: 10.1039/C5OB00058K
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Org. Biomol. Chem., 2015,13, 5418-5423

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    Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7

    A. Udemba, G. Smith, Q.-D. Nguyen, M. Kaliszczak, L. Carroll, R. Fortt, M. J. Fuchter and E. O. Aboagye, Org. Biomol. Chem., 2015, 13, 5418
    DOI: 10.1039/C5OB00058K

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