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Issue 10, 2015
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Reversal of H-bonding direction by N-sulfonation in a synthetic reverse-turn peptide motif

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Abstract

This communication depicts an intriguing example of hydrogen-bonding reversal upon introduction of a sulfonamide linkage at the N-terminus of a synthetic reverse-turn peptide motif. The ready availability of two sulfonyl oxygen atoms, as hydrogen-bonding acceptors, combined with the inherent twisted conformation of sulfonamides are seen to act as switches that engage/disengage the hydrogen-bond at the sticky ends/termini.

Graphical abstract: Reversal of H-bonding direction by N-sulfonation in a synthetic reverse-turn peptide motif

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Publication details

The article was received on 20 Nov 2014, accepted on 13 Jan 2015 and first published on 13 Jan 2015


Article type: Paper
DOI: 10.1039/C4OB02438A
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Org. Biomol. Chem., 2015,13, 3064-3069

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    Reversal of H-bonding direction by N-sulfonation in a synthetic reverse-turn peptide motif

    K. N. Vijayadas, A. S. Kotmale, S. H. Thorat, R. G. Gonnade, R. V. Nair, P. R. Rajamohanan and G. J. Sanjayan, Org. Biomol. Chem., 2015, 13, 3064
    DOI: 10.1039/C4OB02438A

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