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Issue 2, 2015
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Bioorthogonal labelling of 3-nitrotyrosine in peptides and proteins through diazotisation mediated azidation

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Abstract

A new chemical derivatisation method to functionalise peptide and protein bound 3-nitrotyrosine residues is described. By transforming 3-nitrotyrosine to 3-azidotyrosine, the method enables ‘click chemistry’-based labelling of the 3-nitrotyrosine residues and provides new opportunities for the study of this post-translational modification in biological samples.

Graphical abstract: Bioorthogonal labelling of 3-nitrotyrosine in peptides and proteins through diazotisation mediated azidation

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Supplementary files

Article information


Submitted
07 Oct 2014
Accepted
11 Nov 2014
First published
11 Nov 2014

Org. Biomol. Chem., 2015,13, 374-378
Article type
Communication
Author version available

Bioorthogonal labelling of 3-nitrotyrosine in peptides and proteins through diazotisation mediated azidation

J. Y. Ng and J. W. H. Wong, Org. Biomol. Chem., 2015, 13, 374
DOI: 10.1039/C4OB02133A

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