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Issue 10, 2015
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Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

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Abstract

Cucurbiturils (CB6 and CB7) were shown to inhibit the enzymatically catalyzed restriction of plasmids and linear DNA. This effect can be inverted by supramolecular masking of the macrocycles through competitive complexation with polyamines. These experiments provide supramolecular control of biocatalytic processes.

Graphical abstract: Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

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Supplementary files

Article information


Submitted
04 Oct 2014
Accepted
24 Dec 2014
First published
12 Jan 2015

This article is Open Access

Org. Biomol. Chem., 2015,13, 2866-2869
Article type
Communication

Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

C. Parente Carvalho, A. Norouzy, V. Ribeiro, W. M. Nau and U. Pischel, Org. Biomol. Chem., 2015, 13, 2866
DOI: 10.1039/C4OB02122C

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