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Issue 5, 2015
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“AND” luminescent “reactive” molecular logic gates: a gateway to multi-analyte bioimaging and biosensing

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Abstract

This review outlines examples that illustrate a recent and highly innovative concept in the field of (bio)molecular sensing, namely the simultaneous multi-analyte detection using “reactive” luminescent probes that are able to produce an optical signal only in response to multiple (bio)chemical inputs and through covalent chemical reactions with target (bio)analytes. Unlike conventional “AND” molecular logic gates based on supramolecular photochemical mechanisms, these unusual “smart” optical (bio)probes are suitable tools to track the rise and fall of a wider range of biologically relevant analytes, in complex media and with higher selectivity. The potential utility of this concept for in vivo molecular imaging and possible solutions to adapt the described luminogenic processes to far-red or NIR emitters are also discussed.

Graphical abstract: “AND” luminescent “reactive” molecular logic gates: a gateway to multi-analyte bioimaging and biosensing

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Article information


Submitted
29 Sep 2014
Accepted
01 Dec 2014
First published
01 Dec 2014

Org. Biomol. Chem., 2015,13, 1294-1306
Article type
Review Article
Author version available

“AND” luminescent “reactive” molecular logic gates: a gateway to multi-analyte bioimaging and biosensing

A. Romieu, Org. Biomol. Chem., 2015, 13, 1294
DOI: 10.1039/C4OB02076F

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