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Issue 2, 2015
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The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole

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Abstract

The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.

Graphical abstract: The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole

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Publication details

The article was received on 24 Sep 2014, accepted on 15 Oct 2014 and first published on 15 Oct 2014


Article type: Communication
DOI: 10.1039/C4OB02032D
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Org. Biomol. Chem., 2015,13, 365-368

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    The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole

    Y. Wang, J. Qiu, D. Kong, Y. Gao, F. Lu, P. G. Karmaker and F. Chen, Org. Biomol. Chem., 2015, 13, 365
    DOI: 10.1039/C4OB02032D

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