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Issue 2, 2015
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The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole

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Abstract

The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.

Graphical abstract: The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole

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Supplementary files

Article information


Submitted
24 Sep 2014
Accepted
15 Oct 2014
First published
15 Oct 2014

Org. Biomol. Chem., 2015,13, 365-368
Article type
Communication
Author version available

The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole

Y. Wang, J. Qiu, D. Kong, Y. Gao, F. Lu, P. G. Karmaker and F. Chen, Org. Biomol. Chem., 2015, 13, 365 DOI: 10.1039/C4OB02032D

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