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Issue 37, 2015
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Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature

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Abstract

The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic “nanowells” provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.

Graphical abstract: Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature

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Supplementary files

Article information


Submitted
24 Jun 2015
Accepted
27 Aug 2015
First published
01 Sep 2015

This article is Open Access

Nanoscale, 2015,7, 15080-15085
Article type
Communication
Author version available

Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature

J. Junesch, G. Emilsson, K. Xiong, S. Kumar, T. Sannomiya, H. Pace, J. Vörös, S. Oh, M. Bally and A. B. Dahlin, Nanoscale, 2015, 7, 15080
DOI: 10.1039/C5NR04208A

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