Jump to main content
Jump to site search

Issue 37, 2015
Previous Article Next Article

An unusual role of folate in the self-assembly of heparin–folate conjugates into nanoparticles

Author affiliations

Abstract

Tumor targeting agents including antibodies, peptides, and small molecules, are often used to improve the delivery efficiency of nanoparticles. Despite numerous studies investigating the abilities of targeting agents to increase the accumulation of nanosized therapeutics within diseased tissues, little attention has been focused on how these ligands can affect the self-assembly of the nanoparticle's modified polymer constituents upon chemical conjugation. Here we present an actively tumor targeted nanoparticle constructed via the self-assembly of a folate modified heparin. Folate conjugation unexpectedly allowed the self-assembly of heparin, where a majority of the folate molecules (>80%) resided inside the core of the nanoparticle. The folate–heparin nanoparticles could also physically encapsulate lipophilic fluorescent dyes, enabling the use of the constructs as activatable fluorescent probes for targeted in vivo tumor imaging.

Graphical abstract: An unusual role of folate in the self-assembly of heparin–folate conjugates into nanoparticles

Back to tab navigation

Supplementary files

Publication details

The article was received on 19 May 2015, accepted on 29 Jul 2015 and first published on 13 Aug 2015


Article type: Paper
DOI: 10.1039/C5NR03303A
Author version
available:
Download author version (PDF)
Nanoscale, 2015,7, 15185-15190

  •   Request permissions

    An unusual role of folate in the self-assembly of heparin–folate conjugates into nanoparticles

    J. Wang, D. Ma, Q. Lu, S. Wu, G. Y. Lee, L. A. Lane, B. Li, L. Quan, Y. Wang and S. Nie, Nanoscale, 2015, 7, 15185
    DOI: 10.1039/C5NR03303A

Search articles by author

Spotlight

Advertisements