Jump to main content
Jump to site search

Issue 28, 2015
Previous Article Next Article

Hydrous RuO2 nanoparticles as an efficient NIR-light induced photothermal agent for ablation of cancer cells in vitro and in vivo

Author affiliations

Abstract

Metal oxides are receiving an incremental attention in recent years for their potential applications in ablation of cancer cells due to their efficient photothermal conversion and good biocompatibility, but the large sizes and poor photo-stability will seriously limit their practical application. Herein, hydrous RuO2 nanoparticles were synthesized by a facile hydrothermal treatment and surface-modified with polyvinylpyrrolidone (PVP) coating. PVP-coated RuO2 nanoparticles exhibit a well dispertion in saline solution, strong characteristic plasmonic absorption in NIR region, enhanced photothermal conversion efficiency of 54.8% and remarkable photo-stability under the irridation of an 808 nm laser. The nanoparticles were further employed as a new photothermal ablation agent for cancer cells which led rapidly to cellular deaths both in vitro and in vivo.

Graphical abstract: Hydrous RuO2 nanoparticles as an efficient NIR-light induced photothermal agent for ablation of cancer cells in vitro and in vivo

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Feb 2015, accepted on 27 May 2015 and first published on 28 May 2015


Article type: Paper
DOI: 10.1039/C5NR00965K
Nanoscale, 2015,7, 11962-11970

  •   Request permissions

    Hydrous RuO2 nanoparticles as an efficient NIR-light induced photothermal agent for ablation of cancer cells in vitro and in vivo

    Z. Xiao, X. Jiang, B. Li, X. Liu, X. Huang, Y. Zhang, Q. Ren, J. Luo, Z. Qin and J. Hu, Nanoscale, 2015, 7, 11962
    DOI: 10.1039/C5NR00965K

Search articles by author

Spotlight

Advertisements