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Issue 14, 2015
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Mechanical design of DNA nanostructures

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Abstract

Structural DNA nanotechnology is a rapidly emerging field that has demonstrated great potential for applications such as single molecule sensing, drug delivery, and templating molecular components. As the applications of DNA nanotechnology expand, a consideration of their mechanical behavior is becoming essential to understand how these structures will respond to physical interactions. This review considers three major avenues of recent progress in this area: (1) measuring and designing mechanical properties of DNA nanostructures, (2) designing complex nanostructures based on imposed mechanical stresses, and (3) designing and controlling structurally dynamic nanostructures. This work has laid the foundation for mechanically active nanomachines that can generate, transmit, and respond to physical cues in molecular systems.

Graphical abstract: Mechanical design of DNA nanostructures

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Publication details

The article was received on 03 Dec 2014, accepted on 24 Jan 2015 and first published on 06 Feb 2015


Article type: Feature Article
DOI: 10.1039/C4NR07153K
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Nanoscale, 2015,7, 5913-5921

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    Mechanical design of DNA nanostructures

    C. E. Castro, H. Su, A. E. Marras, L. Zhou and J. Johnson, Nanoscale, 2015, 7, 5913
    DOI: 10.1039/C4NR07153K

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