Jump to main content
Jump to site search

Issue 12, 2015
Previous Article Next Article

Leveraging electrokinetics for the active control of dendritic fullerene-1 release across a nanochannel membrane

Author affiliations

Abstract

General adoption of advanced treatment protocols such as chronotherapy will hinge on progress in drug delivery technologies that provide precise temporal control of therapeutic release. Such innovation is also crucial to future medicine approaches such as telemedicine. Here we present a nanofluidic membrane technology capable of achieving active and tunable control of molecular transport through nanofluidic channels. Control was achieved through application of an electric field between two platinum electrodes positioned on either surface of a 5.7 nm nanochannel membrane designed for zero-order drug delivery. Two electrode configurations were tested: laser-cut foils and electron beam deposited thin-films, configurations capable of operating at low voltage (≤1.5 V), and power (100 nW). Temporal, reproducible tuning and interruption of dendritic fullerene 1 (DF-1) transport was demonstrated over multi-day release experiments. Conductance tests showed limiting currents in the low applied potential range, implying ionic concentration polarization (ICP) at the interface between the membrane's micro- and nanochannels, even in concentrated solutions (≤1 M NaCl). The ability of this nanotechnology platform to facilitate controlled delivery of molecules and particles has broad applicability to next-generation therapeutics for numerous pathologies, including autoimmune diseases, circadian dysfunction, pain, and stress, among others.

Graphical abstract: Leveraging electrokinetics for the active control of dendritic fullerene-1 release across a nanochannel membrane

Back to tab navigation

Supplementary files

Article information


Submitted
21 Oct 2014
Accepted
16 Jan 2015
First published
19 Jan 2015

Nanoscale, 2015,7, 5240-5248
Article type
Paper
Author version available

Leveraging electrokinetics for the active control of dendritic fullerene-1 release across a nanochannel membrane

G. Bruno, T. Geninatti, R. L. Hood, D. Fine, G. Scorrano, J. Schmulen, S. Hosali, M. Ferrari and A. Grattoni, Nanoscale, 2015, 7, 5240
DOI: 10.1039/C4NR06209D

Social activity

Search articles by author

Spotlight

Advertisements