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Issue 6, 2015
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Tris-hydroxymethylaminomethane (THAM): a novel organocatalyst for a environmentally benign synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles

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Abstract

A simple, efficient and environmentally benign protocol has been developed for the one-pot, multicomponent synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles using a commercially available, inexpensive, non-toxic, and biodegradable tris-hydroxymethylaminomethane (THAM) as a novel organocatalyst. Ambient reaction conditions, wide scope, avoidance of conventional isolation as well as purification techniques and the reusability of the catalyst for five consecutive runs have improved the practical utility of this multicomponent reaction protocol manifold.

Graphical abstract: Tris-hydroxymethylaminomethane (THAM): a novel organocatalyst for a environmentally benign synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles

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Publication details

The article was received on 18 Dec 2014, accepted on 18 Mar 2015 and first published on 18 Mar 2015


Article type: Paper
DOI: 10.1039/C4NJ02346C
New J. Chem., 2015,39, 4452-4463

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    Tris-hydroxymethylaminomethane (THAM): a novel organocatalyst for a environmentally benign synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles

    K. S. Pandit, P. V. Chavan, U. V. Desai, M. A. Kulkarni and P. P. Wadgaonkar, New J. Chem., 2015, 39, 4452
    DOI: 10.1039/C4NJ02346C

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