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Issue 4, 2015
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Synthesis of amine functionalized graphite nanosheets and their water-soluble derivative for drug loading and controlled release

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Abstract

A facile route to synthesize amine (–NH2) functionalized graphite nanosheets (AFGNS) by 2-step controlled chemical modification of microcrystalline graphite is described. The method begins with nitration by mixed acid (HNO3 : H2SO4 in 1 : 1 v/v ratio), followed by reduction with Na2S to form AFGNS. The AFGNS was reacted with carboxylic acid-terminated polyethylene glycol (PEG) chains (MeO–mPEG–COOH, MW = 5000 Da) in the presence of a carbodiimide coupling agent to obtain a water-soluble PEGylated AFGNS (P-AFGNS) composite. Anticancer drug doxorubicin (DOX) was loaded on this composite with a loading capacity of 0.296 mg mg−1 for an initial concentration of 0.232 mg mL−1 DOX and 0.136 mg mL−1 of P-AFGNS and the release of DOX from this water-soluble DOX loaded P-AFGNS composite at two different temperatures was found to be strongly pH dependent.

Graphical abstract: Synthesis of amine functionalized graphite nanosheets and their water-soluble derivative for drug loading and controlled release

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Supplementary files

Article information


Submitted
10 Sep 2014
Accepted
08 Dec 2014
First published
09 Dec 2014

New J. Chem., 2015,39, 2451-2458
Article type
Paper
Author version available

Synthesis of amine functionalized graphite nanosheets and their water-soluble derivative for drug loading and controlled release

A. Chakravarty, K. Bhowmik, G. De and A. Mukherjee, New J. Chem., 2015, 39, 2451
DOI: 10.1039/C4NJ01545B

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