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Issue 11, 2015
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Tricyclic phenothiazine and phenoselenazine derivatives as potential multi-targeting agents to treat Alzheimer's disease

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Abstract

A group of tricyclic phenothiazines (6a, 6b and 7a–l) and phenoselenazines (12a, 12b and 13a–l) was designed, synthesized and evaluated as multi-targeting ligands aimed at the cholinergic, amyloid and oxidative stress pathways of Alzheimer's disease. The phenothiazine derivative 7j (2-chloro-10H-phenothiazin-10-yl-(4-methoxyphenyl)methanone) was identified as the best dual, non-selective cholinesterase inhibitor (AChE IC50 = 5.9 ± 0.6 μM; BuChE IC50 = 5.3 ± 0.5 μM), whereas in the corresponding phenoselenazine series, 13j (2-chloro-10H-phenoselenazin-10-yl-(4-methoxyphenyl)methanone) exhibited good non-selective cholinesterase inhibition (AChE IC50 = 5.8 ± 0.4 μM; BuChE IC50 = 4.9 ± 0.5 μM). Interestingly, N-10 unsubstituted phenothiazine 6a (AChE IC50 = 7.3 ± 0.6 μM; BuChE IC50 = 5.8 ± 0.5 μM; Aβ1–42 aggregation inhibition = 62%; DPPH scavenging = 92%), and the corresponding phenoselenazine bioisostere 12a (AChE IC50 = 5.6 ± 0.4 μM; BuChE IC50 = 3.0 ± 0.5 μM; Aβ1–42 aggregation inhibition = 45.6%; DPPH scavenging = 84.4%) were able to exhibit multi-targeting ability by demonstrating cholinesterase inhibition, beta-amyloid aggregation and antioxidant properties. These results show that fused tricyclic ring systems based on either phenothiazine or phenoselenazine templates can be useful to develop hybrid small molecules to target multiple pathological routes associated with Alzheimer's disease.

Graphical abstract: Tricyclic phenothiazine and phenoselenazine derivatives as potential multi-targeting agents to treat Alzheimer's disease

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Publication details

The article was received on 28 Jun 2015, accepted on 30 Jul 2015 and first published on 07 Aug 2015


Article type: Concise Article
DOI: 10.1039/C5MD00274E
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Med. Chem. Commun., 2015,6, 1930-1941

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    Tricyclic phenothiazine and phenoselenazine derivatives as potential multi-targeting agents to treat Alzheimer's disease

    G. Tin, T. Mohamed, N. Gondora, M. A. Beazely and P. P. N. Rao, Med. Chem. Commun., 2015, 6, 1930
    DOI: 10.1039/C5MD00274E

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